2 types of solutions to decline according to the level of project development:
The service delivery
The research project (CIR eligible)
- New methods of enzymatic avtivity development
- Simplification of assay methods
- Measure of enzymatic activity on complex formulation
- Enzymatic synthesis of oligosaccharides
- Enzymatic target identification for using in green chemistry
- Biodiversity screenning (Sourcing)
- Cloning, production and caracterization of enzyme
- Enzymatic optimisation by molecular engineering
- Modelling, docking and molecular simulation
- Molecular dynamics
- Statistical study for the engineering of proteins
Enzymes are key elements in most biological mechanisms and are alternatives for the transition from synthetic to green chemistry. D-Zyme's service innovation is based on cutting-edge expertise in enzymatic engineering and enzymology that can be applied to different fields:
FOOD and FEED
SOME OF OUR PARTNERS
PUBLICATIONS (most recent...)
Design of an α-L-transfucosidase for the synthesis of fucosylated HMOs. Saumonneau A, Champion E, Peltier-Pain P, Molnar-Gabor D, Hendrickx J, Tran V, Hederos M, Dekany G, Tellier C. Glycobiology. 2015 Nov 17. pii: cwv099.
Enhancing the chemoenzymatic synthesis of arabinosylated xylo-oligosaccharides by GH51 α-l-arabinofuranosidase. Arab-Jaziri F, Bissaro B, Tellier C, Dion M, Fauré R, O'Donohue MJ. Carbohydr Res. 2015 Jan 12;401:64-72.
Semi-rational approach for converting a GH36 α-glycosidase into an α-transglycosidase. Teze D, Daligault F, Ferrières V, Sanejouand YH, Tellier C. Glycobiology. 2014 Nov 13
De novo design of a trans-β-N-acetylglucosaminidase activity from a GH1 β-glycosidase by mechanism engineering. André-Miral C, Koné FM, Solleux C, Grandjean C, Dion M, Tran V, Tellier C. Glycobiology. 2014 Nov 4.
Semi-rational approach for converting a GH1 β-glycosidase into a β-transglycosidase. Teze D, Hendrickx J, Czjzek M, Ropartz D, Sanejouand YH, Tran V, Tellier C, Dion M. Protein Eng Des Sel. 2014 Jan;27(1):13-9.
Engineering transglycosidase activity into a GH51 α-l-arabinofuranosidase. Arab-Jaziri F, Bissaro B, Dion M, Saurel O, Harrison D, Ferreira F, Milon A, Tellier C, Fauré R, O'Donohue MJ. N Biotechnol. 2013 Jun 25;30(5):536-44.
Alkoxyamino glycoside acceptors for the regioselective synthesis of oligosaccharides using glycosynthases and transglycosidases. Teze D, Dion M, Daligault F, Tran V, André-Miral C, Tellier C. Bioorg Med Chem Lett. 2013 Jan 15;23(2):448-51.
Rational design of a GH1 beta-glycosidase to prevent self-condensation during the transglycosylation reaction. Tran V, Hoffmann L, Rabiller C, Tellier C, Dion M. Protein Eng Des Sel. 2010 Jan;23(1):43-9.
Engineering of glucoside acceptors for the regioselective synthesis of beta-(1->3)-disaccharides with glycosynthases. Marton Z, Tran V, Tellier C, Dion M, Drone J, Rabiller C. Carbohydr Res. 2008 Nov 24;343(17):2939-46.